In 2006, Chen Yi-han made her debut on the screen with the lead role in "Cycling on the Road", for which she won the Best New Performer Award at the 7th Chinese Film Media Awards.

In 2007, she was recognized by more mainland audiences for her role in the inspirational drama "Struggle".

In 2009, she was nominated for the Best Actress at the Seoul International TV Drama Awards for her performance in the police and gangster drama "Bad Boys". Subsequently, she delivered outstanding performances in many works and won the Best Actress Award at the 12th Taipei Film Festival for her role in the drama film "Hearing".

In 2010, the martial arts drama "Meteor, Butterfly and Sword" starring Gu Long was aired.

In 2012, the romantic film "LOVE" in which she starred was released in Taiwan, China. As a result, she was nominated for Best Supporting Actress at the 49th Golden Horse Awards in Taiwan. On December 29th, she released her personal prose photo book "Encounter on the North Island".

In 2014, she was nominated for Best Supporting Actress at the 51st Taiwan Golden Horse Film Awards for her role in the film "Military Paradise".

In 2015, the time-travel film "New Step into the Past", in which she starred, was released throughout China.

In 2016, she starred successively in the romantic comedy "Miss Matchstick and Mr. Delicious" and the suspense film "What I Said is All True".

In 2018, Chen Yihan's first TV drama "Happiness Is Within Reach" and the romantic film "A Story More Sorrowful Than Sadness" in which she starred were successively aired.

In 2021, the thriller "The Bizarre" in which he starred was released.

In October 2022, attended the 57th Golden Bell Awards Ceremony. In December, the urban romance drama "Love Dream Builder", in which she starred alongside Guo Tao, was aired on Sohu Video.

In 2023, participated in the variety show "Ride the Wind 2023".