In 2017, Charles Melton played Reggie Mantle in the TV series "Riverdale".

From 2018 to 2019, the films he/she starred in, such as "The Human Reduction Project 2", "Ariana Grande: Break Up with Your Girlfriend, I'm Bored" and "The Sun is Also a Star", were broadcast one after another.

On January 17, 2020, the film "Bad Boys: Fast Track" in which he starred was released in the United States, in which he played the role of Rafi. On September 5th, he played Charles Melton in the comedy film "Mainstream".

On July 15, 2021, the TV series "American Horror Story Collection Season 1" in which she starred was aired in the United States.

On January 26, 2023, he starred in the crime suspense drama "Poker Face Season 1", in which he played the role of Davis McDowell. On May 20th, the film "May and December" in which he starred was screened at the Cannes Film Festival. He won the Best Supporting Actor Award at the 33rd Gotham Independent Film Awards and the Best Supporting Actor Award at the 12th Boston Online Film Critics Association Awards for this film.

In January 2024, he won the Best Supporting Actor Award at the 2023 National Society of Film Critics Awards for his role in the film "May and December". In February, he/she won the Best Supporting Actor of the Year at the 44th London Film Critics Association Awards. In March, she starred in A24's new war film.

On April 11, 2025, the A24 war-themed film "War" in which she starred was released in North America.