In 2014, she made her debut on the big screen in "Teething" and officially entered the entertainment industry.

In May 2015, she starred in the fantasy suspense film "Planetarium" directed by Rebecca Zrotowski.

In January 2016, the youth comedy film "Yoga Girl Doula" in which she starred premiered at the Sundance Film Festival. In May 2016, I served as the image spokesperson for the promotional video of Chanel's fourth-generation perfume, N°5 L 'Eau No. 5 Water.

In 2017, Lily Rose starred in the musical biopic "The Dancer", which received six nominations at the French Cesar Awards. At the same time, she was also nominated for the Best New Actress at both the French Cesar Awards and the French Luciere Awards for her role as Gredo.

In 2019, he starred in the film "Lancaster King".

In 2024, she played Ellen Hutter in the film "Nosferatu".

The new HBO series "Idol Vortex", starring Lily-Rose Depp, premiered in 2023.