In 2004, he became known to the audience for playing the male lead Liu Chuan in the Haiyan drama "Sunshine Blooms Like a Flower". Afterwards, he continued to make efforts in the field of film and television:

In 2006, she starred in the romantic drama "Thank You for Loving Me";

In 2007, he was awarded the Newcomer of the Year at the Sina Network Awards;

In 2008, she starred in the rural drama "My Home in Dongting Lake, 800 Miles Away";

Participated in the urban emotional drama "Exclusive Disclosure" in 2010;

In 2012, he co starred with Masu in the era suspense drama "Flames".

2013 was a year of rich works for him, not only starring in the first legal work in mainland China, "Gold Medal Lawyer", but also playing the role of "Ding Xiu" in the movie "Embroidered Spring Knife", which left a deep impression.

In 2015, starred in the historical legendary drama "Shaolin Questions" directed by Fu Dongyu;

In 2016, participated in the Eastern magical epic drama "Kyushu: The Story of the Sea Shepherd".

In 2017, Zhou Yiwei experienced a shining moment in his career by participating in the Zhejiang TV program "Birth of Actors" and winning the annual championship. He then attended Milan Fashion Week; In the same year, he participated in the broadcast of "Kyushu Sea Muyun Ji" and also appeared in the movie "The Founding of an Army".

In 2018, the movie "I'm Not a Medicine God" starring was released, and the film received both good reviews and box office success; In the same year, he starred in the historical suspense drama "Chang'an Twelve Hours".

In 2019, his works covered movies and TV dramas. He starred in the movie "Liberation and Final Rescue" with Zhong Hanliang and others, and in the TV drama "Shangyang Fu" with Zhang Ziyi and others. In November, he also appeared in the web drama "Huan Mian". In addition, he starred in the movies "Pizi Lover" and "Brave You".

In February 2024, I will participate in the TV drama "The Great Tang Di Gong Case", and in December, I will specially star in the historical suspense drama "The Code of the River Scene during Qingming Festival";

In 2025, participated in the TV drama "In the Human World", and on July 26th, participated in the broadcast of "Huashan Lunjian".