In 2007, Gan Lu made her debut by starring in the TV drama "Cha Tongxue Youth".

In 2010, she starred as Little Cabbage, who dared to love and hate in the war comedy "Dream Glory 1942".

In 2012, she played Yang Tao, a maid of the Xue family, in the historical drama "The Gate of Heaven".

In 2013, she changed her previous image and played the hot female special forces soldier Tang Xiaoxiao in the contemporary military drama "Special Forces Phoenix".

In 2014, she played the role of psychology PhD Mu Jianyun in the TV series "The Dark One".

In 2015, she starred in "Diablo II" and won the Best Online Drama Award and Outstanding Actor Award at the 3rd China Television Awards for her performance in the drama.

In March 2017, she starred in the modern war drama "Special Forces: Going Deep Behind Enemy Lines", playing the brave and fearless female military doctor Hu Ruirui.

In 2018, she played the role of special agent Lanlin Lin in the crime drama "Cold Flames at the Border".

In 2019, the era detective suspense web drama "Infernal Night of Crime" starring was broadcasted.

In March 2020, the TV drama "Exploring the Republic of China" co starring with Hu Yitian and others was broadcasted.

In March 2021, the action movie "Ghost Drug Lord" in which he starred was released.

In March 2022, starring in the fantasy film "Journey to the West: The Ultimate Treasure" directed by Zeng Xiaoyu, it was released; In May, participated in the TV drama "Forensic Qin Ming's Mind Reader".

In November 2023, the TV drama "Welcome to Maile Village" in which he participated was broadcasted.

On April 20, 2024, the movie "Embroidered Spring Knife: Infernal Inferno" in which she participated was broadcasted on Tencent Video; On June 2nd, the ancient costume romance drama "Mo Yu Yun Jian" was broadcasted.