In 2005, he entered the entertainment industry by playing the role of "Little Nezha" in his first TV drama "Fengshen Bang: Fengming Qishan"

From 2009 to 2013, he successively appeared in TV dramas such as "Home with Aliens", "Naughty Horse Jumping", "Heroes from Ancient Times", and "Return of the Condor Heroes"

In 2015, she starred in the TV drama "Nirvana in Fire" and won the Most Promising Actor Award at the 2015 National Drama Awards for her performance in the drama

From 2018 to 2019, starred successively in the movies "Asura", "Shadow", and "Beloved"

In 2021, the TV dramas "Changge Xing", "Qihang: When the Wind Rises", and the movies "The Future of Summer" and "Me and My Grandparents" were successively released, and were nominated for the Most Media Attention Male Lead at the 19th Film Channel Media Awards

In 2022, Wu Lei starred in "Brilliant Stars" and "The Moon Rises the Sea", and won the Outstanding Young Actor Award at the 2022 China US Television Festival for his performances in these dramas

From 2023 to 2024, starring in urban emotional dramas such as "Just Love" and "At Blizzard Time"

On January 4, 2025, won the annual influential TV drama actor award at the "2024 Tencent Video Starlight Awards"; On January 28th, participated in the "2025 CCTV Spring Festival Gala" and performed the song "Happy New Year"; On June 13th, won the "Quality Actor of the Year" award for the 2025 Weibo Movie Night; On August 8th, the movie "Dongji Island" starring was released