In 2000, Shusuka Ogo made her debut by starring in the stage play "The Story of the National Thieves" produced by the Sunflower Theatre Company.

In May 2002, she starred in the inspiring campus drama "The Great Teacher" by Yuki Nakama.

In 2005, she starred in the film "Zero Year of the North", and due to her outstanding acting skills, she received widespread acclaim and her popularity soared. In the same year, she starred in the film "Memoirs of a Geisha" directed by Rob Marshall, playing the young Yuri, and won the Newcomer Award at the 15th Japan Film Critics Awards.

In 2007, she starred alongside Kenichi Matsuyama in the comedy adaptation of the manga "Seven Color Sound and Wakaba", and won the Supporting Actress Award at the 53rd Nikkan Drama Academy Awards for this role.

In 2010, she starred in the Japanese drama SP "Fukuzo", marking her first time taking on the lead role in a Japanese drama in her 10-year career.

In August 2012, she starred in the campus ensemble film "It's Said that Kirijima is Leaving the Club".

In 2014, she starred in the social drama "Mom Won't Be Here Tomorrow" alongside child stars such as Aina Ueda and Riko Suzuki.

On June 29, 2024, the film "Ghosts Have CaprIcious Dreams" in which she starred was released.