In 2006, she made her debut after ranking 4th in the "Handsome Boy" competition of Tokyo Graffit magazine and was spotted by her agent.

In 2010, she won the Best Newcomer Award at the 19th Hashida Awards in Japan and the Newcomer of the Year Award at the 35th Elan d'or for the morning drama "Gegege no Kitaro's Wife". In the same year, she won the Best Newcomer Award at the 32nd Yokohama Film Festival for her role in the inspirational film "Rock New Band".

In 2011, she made her debut in the Taiga drama "River: The Warring States of the Princesses". In the same year, the drama film "We Can't Change the World" in which she starred was released.

In 2013, he played the male lead Wu Gubu in the drama film "Yellow Elephant".

In 2014, the comedy film "Brother and Sister Onodera" in which she starred was released.

In 2016, the suspense drama "Black Tree Sea" in which she starred was aired.

In November 2019, Ri Mukai starred in the Fuji TV drama "The Secret of 10".

On January 19, 2020, the Taiga drama "Kirin Is Coming" in which she starred was aired.

In April 2021, the TV drama "The Splendid Clan" in which she starred was aired. Starred in the TV drama "There's a Reason for Dressing Up in Love".

On March 12, 2022, the film "Wedding High" in which she starred was released. On April 13th, the TV drama "Evil Girl ~ Who Says Work Isn't Cool? ~" in which she starred was aired. On November 24th, the Netflix original series "First Love" starring him/her will be available.

On March 17, 2023, the TV drama "Angel Flight" in which she starred was aired. On July 7th, the TV drama "Police Department Assistant Demon God" in which he starred was aired. On September 27th, the film "Party Vagabond Kongming" in which he starred was released.

On February 18, 2024, the TV drama "Compiling a Boat - I Want to Compile a Dictionary -" in which she starred was aired. On June 29th, the second season of "Double-faced Scammers and False Police" in which he participated was aired. In October, the TV drama "The Lion's Hiding Place" in which he/she starred was aired.

On March 25, 2025, the TV drama "Fujiko F. Fujio SF Short TV Series Season 3" in which he starred was aired. On April 25th, the film "Party Vagabond Zhuge Kongming" in which he starred was released.